Evidence map›Paper›PMID 41972454›Full record

ArticleEuropean journal of immunology2026

Increased Constitutive Interferon-β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein.

Hanspeter Pircher, Oliver S Thomas, Anne S Haefke, Annette Oxenius, Thomas Boehm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CD8 T Cell Sensing of Type I Interferon Impacts Anergy.European journal of immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanspeter PircherMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Oliver S ThomasMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Anne S HaefkeInstitute of Microbiology, ETH Zurich, Zurich, Switzerland.
Annette OxeniusInstitute of Microbiology, ETH Zurich, Zurich, Switzerland.
Thomas BoehmMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

Funding

Tetramer Research & Development Contract (Influenza)75N93020D00005 · NIAID · EMORY UNIVERSITY · PI ALTMAN, JOHN · 2020 to 2025
$18.3M
Max-Planck-Gesellschaft and by the Schweizerische NationalfondsNIH Tetramer Core Facility 75N93020D00005
6 · The paper itself

Abstract

Besides the strong Type I interferon (IFN-I) response induced by infections, IFN-I is also produced constitutively at lower levels. Constitutive IFN-I production is regulated by resident microbiota and is essential for induction of efficient immune responses. Here, we demonstrate in transgenic (tg) mice that expression of a single viral envelope gene, the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), increased constitutive IFN-β levels and induced numerous IFN-stimulated genes (ISGs). In addition, self-antigen-driven CD44

Indexed as

CD4-Positive T-LymphocytesGlycoproteinsInterferon-betaLymphocytic choriomeningitis virusViral Envelope ProteinsAnimalsHomeostasisImmunologic MemoryLymphocytic ChoriomeningitisMiceMice, Inbred C57BLMice, TransgenicSignal TransductionGlycoproteinsInterferon-betaViral Envelope Proteinshomeostasisinterferonlymphocytic choriomeningitis virus (LCMV)

Identifiers

PMID41972454
PMCPMC13073064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.