Evidence map›Paper›PMID 41972436›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

PSMA8-Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility.

Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huiwen CaoMOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Qianting ZhangZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, China.
Wei XuMOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Anxuan FangMOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Haomang XuMOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Cheng QiuMOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Lugeng HeDepartment of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Chao YuMOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0001-9798-2992

Funding

Fundamental Research Funds for the Central Universities 226-2024-00032Fundamental Research Funds for the Central Universities K20220228National Natural Science Foundation of China 32200671National Natural Science Foundation of China 32222029National Natural Science Foundation of China 32500748National Natural Science Foundation of China 32571000National Natural Science Foundation of China 82171598National Natural Science Foundation of China 82271380National Natural Science Foundation of China 82574000the China Postdoctoral Science Foundation 2025M772553the State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital BYSYSZKF2024010Zhejiang Provincial Natural Science Fund LR21C120001Zhejiang Provincial Natural Science Fund LZ26C120001
6 · The paper itself

Abstract

Proteasome experiences sophisticated dynamics in types, quantities, and activities during spermiogenesis. However, the physiological importance of proteasomal degradation in mammalian spermiogenesis remains largely unknown. Here, we report that the PSMA8-containing spermato-20S proteasome (s20S) is required for spermiogenesis and male fertility in mice. In a mutant mouse model that the C-terminal 30-amino-acid (C30) of PSMA8 is substituted by PSMA7-C30, the resulting PSMA8

Indexed as

FertilityProteasome Endopeptidase ComplexSpermatogenesisAnimalsMaleMiceTestisUbiquitinationProteasome Endopeptidase ComplexproteasomePSMA8s20Sspermiogenesis

Identifiers

PMID41972436
PMCPMC13334872

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.