Evidence map›Paper›PMID 41972414›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression.

Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jianyun JiangCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Yan WangCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Yi QinCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Luohai ChenCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Xiaowu XuCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Guixiong FanCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Desheng JingCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Miaoyan WeiCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Xianjun YuCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Junfeng XuCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Shunrong JiCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.
Jie ChenCenter For Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID https://orcid.org/0000-0001-8113-3515

Funding

National Natural Science Foundation of China 82203655National Natural Science Foundation of China 82403878National Natural Science Foundation of China 82473108National Natural Science Foundation of China 82530088National Natural Science Foundation of China 82573923National Natural Science Foundation of China U21A20374Natural Science Foundation of Shanghai Municipality 25ZR1401065Science and Technology Commission of Shanghai Municipality 25TS1403500Science and Technology Commission of Shanghai Municipality YDZX20243100002003
6 · The paper itself

Abstract

Pancreatic neuroendocrine tumors (PanNETs) frequently exhibit loss or reduced expression of the tumor suppressor MEN1, a key regulator of tumor progression and DNA damage response (DDR). However, the upstream mechanisms driving MEN1 silencing remain unclear. Here, a pooled epigenetic CRISPR-Cas9 screen identified the NAD

Indexed as

Neuroendocrine TumorsPancreatic NeoplasmsRadiation ToleranceSirtuinsAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleMiceSIRT7 protein, humanSirtuinsDNA damage responseMEN1pancreatic neuroendocrine tumorsradiotherapySIRT7

Identifiers

PMID41972414
PMCPMC13335021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.