Evidence map›Paper›PMID 41972391›Full record

ArticleJournal of applied clinical medical physics2026

Preliminary treatment planning strategy for blood dose reduction in head and neck radiotherapy.

Seohan Kim, Jieun Han, Wonmo Sung, Sebastian Tattenberg

Abstract readEvaluation Study
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In one paragraph

Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seohan KimDepartment of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-7936-3039
Jieun HanDepartment of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Wonmo SungDepartment of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-0172-0646
Sebastian TattenbergSchool of Natural Sciences, Laurentian University, Sudbury, Ontario, Canada.

Funding

2024 Health Fellowship FoundationBasic Medical Science Facilitation Program through the Catholic Medical Center of the Catholic University of Korea funded by the Catholic Education FoundationMitacs fellowshipNational Research Foundation of Korea 2021R1C1C1005930National Research Foundation of Korea RS-2025-25419443
6 · The paper itself

Abstract

backgroundRadiation dose to circulating blood, a surrogate for circulating lymphocyte damage by radiotherapy (RT), has emerged as a factor predicting treatment outcomes, including overall survival, tumor recurrence, and lymphopenia occurrence. This study aimed to investigate strategies for reducing circulating blood dose in head and neck cancer (HNC) patients by comparing treatment plans, the implementation of which varied by modality and blood vessel-sparing (BVS) approach. MATERIALS AND

methodsUsing a publicly available dataset, 20 HNC patients were randomly selected and a total of 120 treatment plans were generated using RayStation. For each of the two modalities, including intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT), three planning strategies were evaluated: a conventional plan (Conv) and two blood vessel-sparing plans with mean dose constraints targeting 90% and 80% of the conventional vessel dose (BVS-90% and BVS-80%, respectively). Blood dose was estimated using the HEDOS simulation framework.

resultsIMPT reduced circulating blood dose compared to IMRT, lowering the mean blood dose by 21.5% and D

conclusionsIn this preliminary planning study, incorporating blood-rich structures as OARs and adopting IMPT effectively reduced blood dose. Integrating blood dose considerations into RT planning is readily implementable within existing clinical workflows to minimize lymphocyte damage.

Indexed as

Head and Neck NeoplasmsOrgans at RiskRadiation InjuriesRadiometryRadiotherapy Planning, Computer-AssistedAdultAgedAged, 80 and overBlood VesselsComputer SimulationDatasets as TopicFeasibility StudiesFemaleHumansLymphocytesMaleblood doseblood vessel‐sparing RThead and neck cancerplanning studytreatment plan optimization

Identifiers

PMID41972391
PMCPMC13072057

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.