ArticleCancer medicine2026
Dynamic Predictors for Malignancy Risk of Follicular Thyroid Neoplasms: A Real-World, 10-Year Cohort Study.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dynamic Predictors for Malignancy Risk of Follicular Thyroid Neoplasms: A Real-World, 10-Year Cohort Study.Cancer medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveThe malignancy risk of follicular thyroid neoplasms (FTN) is variable, yet most studies rely on static, single-time-point assessments without monitoring dynamic changes.
methodsWe included patients who received two or more preoperative ultrasound examinations and were diagnosed with follicular thyroid carcinoma (FTC) or follicular thyroid adenoma (FTA) after surgery. We first identified 11 key predictors for the malignancy risk of FTN, comprising five static predictors (age, sex, body mass index, baseline mean tumor diameter, and surveillance duration) and six dynamic predictors [average thyroid-stimulating hormone (TSH) level, TSH instability, weighted rate and instability of mean diameter, and changes in tumor margin and calcifications over time]. Then, we applied logistic regression to evaluate the association between each dynamic predictor and the malignancy risk of FTN, adjusting for the static predictors as potential confounders.
resultsThe results showed that a higher average TSH level was associated with a decreased risk of malignancy in FTN [odds ratio (OR): 0.67; 95% confidence interval (CI): 0.49, 0.92]. However, a shift in margin from circumscribed to irregular or maintaining an irregular margin was associated with a higher risk of malignancy [OR (95% CI): 4.18 (1.49, 11.71) and 5.33 (2.51, 11.35)]. We observed no association between the rate or instability of the mean tumor diameter and the malignancy risk of FTN.
conclusionChanges in tumor margins (to irregular or lobulated) and lower average TSH levels were key predictors of a higher malignancy risk, while the rate or instability of tumor growth might play a minor role.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.