ArticleFrontiers in neuroscience2026
Systemic metabolic reprogramming within 24 h predicts delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Delayed cerebral ischemia (DCI) remains a major determinant of poor outcomes after aneurysmal subarachnoid hemorrhage (aSAH), yet early risk stratification is challenging. Methods: A retrospective cohort of 44 aSAH patients was analyzed (DCI, Results: The DCI group was older, had a higher proportion of females, worse admission neurological status, higher vasospasm incidence, and lower hemoglobin. Vasospasm and age were independent predictors. Aneurysm morphological parameters showed no between-group differences. Metabolic profiles showed clear separation, supported by permutation testing ( Conclusion: Early serum metabolomics within 24 h after aSAH revealed a DCI-associated systemic metabolic signature, supporting the identification of exploratory serum metabolic features associated with DCI in a Chinese cohort, which may inform future biomarker development following targeted validation.
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