ArticleFrontiers in immunology2026
The neutrophil-to-lymphocyte ratio is associated with adverse outcomes in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The neutrophil-to-lymphocyte ratio (NLR) is a convenient biomarker reflecting systemic inflammation and immune balance. While its prognostic value is established in other diseases, its role in predicting long-term outcomes in patients with ANCA-associated vasculitis (AAV) remains unclear. This study aimed to investigate the association between NLR and organ involvement, all-cause mortality, and end-stage renal disease (ESRD) in AAV patients. Methods: We conducted a retrospective study of 532 patients first diagnosed with AAV at Tianjin Medical University General Hospital between June 2012 and June 2024. The primary outcome was all-cause mortality, and the secondary outcome was ESRD. Logistic regression was used to assess associations between NLR and organ involvement. Restricted cubic spline (RCS), Cox proportional hazards regression, Kaplan-Meier survival analysis, time-dependent receiver operating characteristic (ROC) and subgroup analysis were employed to analyze the association between NLR and outcomes in AAV patients. Results: At baseline, patients with higher NLR level exhibited more severe inflammation, worse renal function, and higher disease activity (all Conclusion: A nonlinear relationship with a saturation effect was observed between NLR and all-cause mortality in AAV patients. An elevated NLR served as an independent risk factor for adverse outcomes. This simple biomarker could be valuable for risk stratification in AAV patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.