Evidence map›Paper›PMID 41972138›Full record

ArticleFrontiers in immunology2026

Endothelial cells regulate mesangial cells through the Dll4/Notch3 axis to participate in glomerular injury in lupus nephritis.

Haixia Guo, Yueying Mao, Yongjun Wang, Bin Yu, Zhifeng Gu, Chun Yao, Zhanyun Da

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Haixia Guo *Department of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Yueying Mao *Department of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Yongjun WangKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Bin YuKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Zhifeng GuDepartment of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Chun YaoKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Zhanyun DaDepartment of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Increasing evidence suggests that microvascular dysregulation mediates mesangial cell (MC) alteration in the pathogenesis of LN (Lupus nephritis). However, the heterogeneity of endothelial cells (ECs) in LN and their regulatory mechanisms on MCs have not been thoroughly investigated. Objective: To elucidate the regulatory role and mechanism of ECs in the development and progression of LN. Methods: We analyzed EC heterogeneity and cell-cell interactions in the kidneys of LN mice using single-nucleus RNA sequencing (snRNA-seq). Results: We found that the number of ECs was increased during LN process and ECs exhibited cellular heterogeneity, among which EC subcluster EC-1 was identified as a potential regulator of MCs, possibly through the Dll4/Notch3 axis. Conclusions: Our findings suggest that abnormal EC activation may be associated with LN progression, potentially through promoting MC migration and proliferation via the Dll4/Notch3 axis. This study reveals a candidate molecular axis in the progression of LN and provides preliminary preclinical insights for future investigation into therapeutic strategies in LN.

Indexed as

Adaptor Proteins, Signal TransducingCalcium-Binding ProteinsEndothelial CellsKidney GlomerulusLupus NephritisMesangial CellsReceptor, Notch3AnimalsCoculture TechniquesFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceSignal TransductionAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, humanDLL4 protein, mouseIntracellular Signaling Peptides and ProteinsMembrane ProteinsNOTCH3 protein, humanNotch3 protein, mouseReceptor, Notch3Dll4/Notch3endothelial cellslupus nephritismesangial cellstarextumab

Identifiers

PMID41972138
PMCPMC13062793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.