Evidence map›Paper›PMID 41972132›Full record

ArticleFrontiers in immunology2026

Itaconate ameliorates cardiovascular inflammation in a mouse model of Kawasaki disease vasculitis - brief report.

Youngho Lee, Takahiro Namba, Asli E Atici, Emily Aubuchon, Malcolm E Lane, Benjamin L Ross, Magali Noval Rivas, Moshe Arditi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Youngho Lee *Department of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Takahiro Namba *Department of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Asli E AticiDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Emily AubuchonDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Malcolm E LaneDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Benjamin L RossDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Magali Noval RivasDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.
Moshe ArditiDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Kawasaki disease (KD), a systemic vasculitis and the leading cause of acquired heart disease in children, stems from an uncontrolled inflammatory response that fails to resolve in up to 20% of IVIG-treated patients. This treatment resistance increases the risk of cardiovascular complications and highlights the need for more targeted therapeutics. Methods: We used the Results: LCWE injection led to the development of cardiovascular lesions, specifically aortitis, coronary arteritis, and abdominal aorta dilatation. Expression of Conclusions: Itaconate treatment provides cardiovascular protection in an experimental mouse model of KD vasculitis by decreasing NLRP3 inflammasome activation and reducing vascular inflammation. Itaconate may be a promising therapeutic agent for patients with KD.

Indexed as

Anti-Inflammatory AgentsMucocutaneous Lymph Node SyndromeSuccinatesAnimalsCarboxy-LyasesDisease Models, AnimalFemaleHumansHydro-LyasesInflammasomesInflammationInterleukin-1betaLacticaseibacillus caseiMaleMiceNLR Family, Pyrin Domain-Containing 3 ProteinACOD1 protein, humanAcod1 protein, mouseAnti-Inflammatory AgentsCarboxy-LyasesHydro-LyasesInflammasomesInterleukin-1betaitaconic acidNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSuccinatesIL-1βitaconateKawasaki diseaseNLRP3vasculitis

Identifiers

PMID41972132
PMCPMC13065724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.