ReviewFrontiers in aging neuroscience2026
Structural and functional brain alterations in depression with Alzheimer's disease and mild cognitive impairment: a multimodal coordinate-based meta-analysis.
Review in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression is a common neuropsychiatric symptom in Alzheimer's Disease (AD) and mild cognitive impairment (MCI). Inconsistent results for comparison between AD with depression (ADD), MCI with depression (MCID), and those without depression were obtained from previous neuroimaging studies. Therefore, a multimodal coordinate-based meta-analysis was conducted in this study. Methods: We searched PubMed, Embase, PsycINFO and the Cochrane Library for neuroimaging studies on ADD and MCID patients from December 1995 to December 2025. Activation likelihood estimate (ALE) coordinate-based meta-analyses were performed to explore brain regions showing abnormalities in ADD and MCID compared to AD without depression (ADND) and MCI without depression (MCIND). Moreover, we performed modality and subgroup analysis of the difference in structural and neural activity. Results: A total of 30 studies, comprising 1973 participants (520 ADD patients, 297 MCID patients, 748 ADND patients, and 408 MCIND patients), were included in this meta-analysis. ADD and MCID showed significantly decreased gray matter volume (GMV) in the right hippocampus and neural activity in the right superior frontal gyrus (SFG) and left inferior temporal gyrus (ITG) compared to ADND and MCID. Subgroup analysis revealed decreased neural activity in the left SFG in the ADD group compared to the ADND group, and decreased neural activity in the right SFG and left ITG in the MCID group compared to the MCIND group. Conclusion: Our findings that decreased GMV of the hippocampus and abnormal neural activities of SFG and ITG in ADD and MCID expand novel insights into the neural mechanisms of depression in AD and MCI, representing potential neural correlates for depression in ADD and MCID.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.