ArticleFrontiers in aging neuroscience2026
Long-term outcomes after caudal zona incerta-forel field ablation: three-year clinical follow-up in advanced Parkinson's disease.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Introduction: Advanced Parkinson's disease (PD) with a tremor-rigid phenotype poses therapeutic challenges when pharmacological treatments lose efficacy and deep brain stimulation (DBS) is not an option; particularly in contexts where access to implantable neuromodulation therapies is limited. In this scenario, stereotactic ablation of the caudal zona incerta (cZI) and the Fields of Forel has emerged as a surgical alternative, although long-term evidence remains scarce, especially for combined infrathalamic approaches. Methods: A prospective study was conducted in 10 patients with advanced unilateral PD and a tremor-rigid phenotype, treated with stereotactic radiofrequency in the cZI and Fields of Forel. Motor function was assessed using the UPDRS III at six time points (baseline, 3, 6, 12, 24, and 36 months), allowing the analysis of both early response and long-term clinical stability. Paired Student's Results: UPDRS III scores were significantly reduced at all follow-ups ( Conclusion: Stereotactic ablation of the cZI and Fields of Forel provides robust and sustained clinical benefits at 3 years, with a favourable safety profile. These findings highlight the durability of the motor effect of infrathalamic ablative approaches and position this technique as a viable alternative to DBS in selected patients with advanced PD; underscoring the need for multicentre studies to consolidate its role in contemporary functional surgery.
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