Evidence map›Paper›PMID 41971993›Full record

ArticleiScience2026

Conserved post-odor dynamics in the olfactory systems of mice and locusts.

Elizabeth H Moss, Doris Ling, Cameron L Smith, Feiyang Deng, Ryan Kroeger, Jacob Reimer, Baranidharan Raman, Benjamin R Arenkiel

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dense and Persistent Odor Representations in the Olfactory Bulb of Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth H MossDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Doris LingDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63105, USA.
Cameron L SmithDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Feiyang DengDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63105, USA.
Ryan KroegerDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Jacob ReimerDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Baranidharan RamanDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63105, USA.
Benjamin R ArenkielDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
Multilevel Analysis of Neuronal Computations Underlying the Robust Encoding of Sensory Information in the Mammalian Olfactory SystemUF1NS111692 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R, PFAFFINGER, PAUL · 2019 to 2019
$4.5M
MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6M
Mechanisms of basal forebrain control over sensory processingR00DC019505 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MOSS, ELIZABETH HANSON · 2023 to 2025
$722k
NICHD NIH HHS U54 HD083092NIDCD NIH HHS R00 DC019505NIDDK NIH HHS R01 DK109934NINDS NIH HHS R01 NS078294NINDS NIH HHS UF1 NS111692
6 · The paper itself

Abstract

Interpreting chemical information and translating it into ethologically relevant output is a shared challenge of olfactory systems across species, but are olfactory computations conserved across species to overcome these common challenges? To investigate this, we compared neural activity in the locust antennal lobe (AL) and mouse olfactory bulb (OB) both during and after odor presentations. We found that odors activated nearly mutually exclusive neural ensembles during odor presentations ("ON response") and after the termination of the odor stimulus ("OFF response"). ON and OFF responses evoked by a single odor were anticorrelated with each other. Inverted OFF responses persisted long after odor termination in both AL and OB, and enhanced contrast between odors that were experienced close together in time. Together our results show how post-odor neural activity, relative to odor-evoked activity, is similar across two distinct species, revealing a conserved mechanism for enhancing contrast between odors at the neural level.

Indexed as

biological sciencesneurosciencesensory neuroscience

Identifiers

PMID41971993
PMCPMC13066794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.