Evidence map›Paper›PMID 41971991›Full record

ArticleiScience2026

A stress-induced PI3P complex controls autophagy in erythroid precursors.

Pooja Roy, Blake A Rose, Suhita Ray, Venkatasai R Dogiparthi, Meg A Schaefer, Cheryl L Stucky, Suyong Choi, Nicholas T Woods, Kyle J Hewitt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Pooja RoyDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
Blake A RoseDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
Suhita RayDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
Venkatasai R DogiparthiDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
Meg A SchaeferDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
Cheryl L StuckyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Suyong ChoiEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Nicholas T WoodsEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Kyle J HewittDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

Unexpected roles of phosphoinositides in the nucleusR35GM150504 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Suyong Choi · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM150504
6 · The paper itself

Abstract

Samd14 coordinates stem cell factor/Kit receptor signaling and is crucial for the survival of erythroid precursors in anemia contexts. Here, we show that Samd14 is needed to maintain balanced autophagy in erythroid precursors following acute anemia. Autophagy-associated gene signatures and protein levels are deregulated when erythropoiesis accelerates in acute anemia. Mechanistically, Samd14 interacts via its SAM domain with phosphatidylinositol 3-phosphate (PI3P), an integral component of endosomal and autophagic membranes. Pharmacologic inhibition of VPS34, the class III PI 3-kinase that generates PI3P, impaired erythroid differentiation specifically in stress contexts. Loss of Samd14 shifted the sensitivity of erythroid precursors to VPS34 inhibition, where higher doses were required to block differentiation. Given the critical roles of autophagy in normal differentiation, Samd14's stress-dependent activation and roles in autophagy suggest that this mechanism is needed to maintain progenitor levels and balance the production of healthy, mature red blood cells in anemia.

Indexed as

cell biologymolecular biology

Identifiers

PMID41971991
PMCPMC13062518

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.