Evidence map›Paper›PMID 41971985›Full record

ArticleiScience2026

Serglycin modulates inflammation and metabolism in macrophages.

Shirin Porteymour, Saikat Das Sajib, Susannah von Hofsten, Atanaska I Doncheva, Christina D Bjørnvall, Beate Hegge, Mélina Gautier, Mirjana Grujic, Pratibha Kolan, Karthickeyan Chella Krishnan and 6 more

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shirin PorteymourDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Saikat Das SajibDepartment of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Susannah von HofstenDepartment of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Atanaska I DonchevaDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Christina D BjørnvallDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Beate HeggeDepartment of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Mélina GautierDepartment of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Mirjana GrujicDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Pratibha KolanDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Karthickeyan Chella KrishnanDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
Jason MatthewsDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Knut T DalenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Gunnar PejlerDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Svein O KolsetDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Erik KnutsenDepartment of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Frode A NorheimDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serglycin is a key hematopoietic proteoglycan that regulates the storage and retention of proteases, cytokines, and chemokines within immune-cell secretory granules. We previously identified serglycin as the predominant proteoglycan secreted by macrophages and a regulator of tumor necrosis factor-α (TNF-α) release following lipopolysaccharide (LPS) stimulation. Here, we analyzed serglycin expression in peritoneal macrophages from 92 mouse strains in the hybrid mouse diversity panel (HMDP) after LPS exposure and investigated its role in M1 polarization using serglycin-deficient murine bone marrow-derived macrophages and human THP-1 macrophages stimulated with LPS and interferon-γ (IFN-γ). Serglycin upregulation is strongly associated with M1 polarization and correlated with TNF-α and IFN-γ transcriptional signatures across models. Integrated transcriptomic and secretome analyses revealed a marked discordance between mRNA and protein output in serglycin-deficient macrophages, with impaired cytokine secretion despite elevated transcript levels, validated by RT-qPCR and ELISA. Loss of serglycin additionally affected macrophage metabolism, vesicle biogenesis, phagocytosis, and extracellular reactive oxygen species generation, identifying serglycin as a key regulator of macrophage polarization and functional programming.

Indexed as

cell biologyimmunologymolecular biology

Identifiers

PMID41971985
PMCPMC13062519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.