ArticleChem2026
ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors.
Article in Chem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Chemical Synthesis of Mirror-Image Proteins Reveals Chirality-Dependent Cellular Uptake Mediated by a Cell-Penetrating Peptide.Journal of the American Chemical Society · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein therapeutics have transformed drug discovery by enabling modulation of challenging targets inaccessible to small molecules. However, most proteins lack the ability to penetrate cells, where many critical drug targets reside. Here, we present reCHEMbinant protein engineering, a strategy designed to generate synthetically enhanced proteins with improved structural stability, serum resistance, and cellular uptake. Applying this approach to Omomyc, a protein-based MYC inhibitor, we developed several reCHEMbinant stapled variants (HeloMYCs) exhibiting low-nanomolar DNA-binding affinity. Notably, the
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Registered trials
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