ReviewFrontiers in dental medicine2026
Preparation protocols and periodontal applications of platelet rich fibrin, a review.
Review in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood concentrates, such as platelet rich plasma and platelet rich fibrin, have been proposed to speed up tissue healing and regeneration in many dental fields. This was based on the fact that upon platelet activation, α-granules, which are reservoirs for many growth factors, fuse with the plasma membrane and release their cargo. The released growth factors exhibit chemotactic and mitogenic properties that promote and modulate cellular functions involved in tissue healing, cell proliferation, and tissue regeneration. Platelet rich fibrin (PRF) products were introduced as a grafting biomaterial to be used in surgical periodontics, because of their regenerative qualities. PRF variants are totally autogenous, easy to prepare, fast, economic and most importantly, they do not involve a donor site, therefore PRF was suggested as a connective tissue graft (CTG) substitute, to avoid complications relating to the second surgical site to harvest the CTG. It is important to highlight that the quality and the content of the PRF matrix depends largely on the preparation conditions of the patients' blood sample. Based on the centrifugation speed of the extracted blood, different PRF matrices can be produced, such as Leukocyte- platelet rich fibrin (L-PRF), Advanced platelet rich fibrin (A-PRF) and Advanced platelet rich fibrin plus (A-PRF+), in addition to the injectable form of platelet rich fibrin (i-PRF) and lyophilised PRF (Ly-PRF). All these variants are currently used in different dental and periodontal procedures. This article aims to provide an overview of different PRF preparations and their applications in periodontal surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.