Evidence map›Paper›PMID 41971944›Full record

ArticleComputational and structural biotechnology journal2026

Salivary Proteomic Signatures Reveal Novel Mechanistic Insights into Moderate Dental Fluorosis Pathogenesis and Oral Homeostasis Disruption.

Ansaya Pumchan, Patcharaporn Gavila, Thutchima Khieota, Han-Sung Jung, Kanokwan Sriwattanapong, Thantrira Porntaveetus

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ansaya PumchanCenter of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0001-7802-2064
Patcharaporn GavilaIntercountry Centre for Oral Health, Department of Health, Ministry of Public Health, Chiang Mai 50000, Thailand.
Thutchima KhieotaCenter of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.
Han-Sung JungDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
Kanokwan SriwattanapongCenter of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.
Thantrira PorntaveetusCenter of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0003-0145-9801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moderate dental fluorosis (MF) represents a pivotal yet understudied stage of enamel fluorosis, characterized by distinct opacities indicating substantial but incomplete enamel disruption. Despite its prevalence, the molecular basis underlying this transitional phenotype remains unclear. This study employed a system proteomic approach to delineate salivary proteomic alterations associated with MF and to elucidate their biological and mechanistic implications. Unstimulated whole saliva was collected from school-aged children with MF (

Identifiers

PMID41971944
PMCPMC13068020

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.