Evidence map›Paper›PMID 41971827›Full record

ArticleFundamental research2026

Cancer-associated fibroblast-derived stanniocalcin 1 promotes cholangiocarcinoma progression and lymph node metastasis.

Jian Yan, Qinqin Liu, Gang Xiao, Jiajia Du, Caini Yang, Chaoqun Liu, Shusheng Lin, Zhenhua Bai, Chao Liu, Jingang Huang and 1 more

Abstract read
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In one paragraph

Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian YanDepartment of Hepatobiliary surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
Qinqin LiuDepartment of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Gang XiaoDepartment of Thoracic Surgery, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510641, China.
Jiajia DuGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Caini YangDepartment of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Chaoqun LiuDepartment of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China.
Shusheng LinDepartment of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Zhenhua BaiDepartment of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Chao LiuDepartment of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Jingang HuangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Rui ZhangDepartment of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a fibroblast-rich tumor. Lymph node metastasis (LNM) is the main prognostic risk factor for CCA. We determined that stanniocalcin 1 (STC1) is highly expressed in cancer-associated fibroblasts (CAFs) with LNM in CCA. However, the roles of CAFs and STC1 in CCA progression and LNM remain unelucidated. Here, we demonstrated that primary CCA tissues with LNM (LN

Indexed as

Cancer-associated fibroblastsCholangiocarcinomaIntegrinLymph node metastasisStanniocalcin 1

Identifiers

PMID41971827
PMCPMC13069643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.