Evidence map›Paper›PMID 41971825›Full record

ReviewFundamental research2026

Mechanical communication and function regulation of immune cells.

Chen Yang, Ruipei Xie, Ting Cao, Yiyu Zhang, Xiaochen Wang, Ye Xu, Qihui Fan, Fangfu Ye

Abstract readReview
In one paragraph

Review in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chen YangSchool of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China.
Ruipei XieBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Ting CaoThe First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yiyu ZhangBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Xiaochen WangBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Ye XuSchool of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China.
Qihui FanBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Fangfu YeBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the pivotal components of the immune system, immune cells can migrate rapidly and with flexibility to fulfill their critical functions. The cytoskeleton and mechano-sensitive proteins anchored within them play a crucial role in mechano-transduction, facilitating the conversion of mechanical signals into responses within the immune cells when they encounter external stimuli. In recent years, an increasing number of studies have revealed that mechanical signals play important roles in the immune response. This article reviews advanced techniques for analyzing cellular-level mechanical forces and provides insights into the current understanding of mechanical signals in the immune system. It describes how mechano-sensitive proteins collaborate to mediate mechano-transduction and examines the profound impact of mechanical signals on immune cell functions. This review highlights the growing importance of mechano-biology in the immune system and offers a glimpse of exciting future developments in this emerging field.

Indexed as

Immune cellsMechanical cytoskeletonMechano-sensitive proteinsMechano-transductionMicro-environment

Identifiers

PMID41971825
PMCPMC13069623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.