ReviewFundamental research2026
New opportunities and challenges for nonshedder tumors.
Review in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer remains a leading cause of mortality worldwide. While surgical resection effectively controls localized tumors, postoperative recurrence remains a significant challenge. Circulating tumor DNA (ctDNA), a key biomarker in liquid biopsy, has garnered considerable attention for its non-invasive nature and high specificity in monitoring cancer recurrence. However, some patients exhibit ctDNA nonshedding characteristics before surgery, and the underlying mechanisms remain unclear. This review examines the distinctive features of nonshedder tumors, highlighting the influence of tumor stage, metabolic activity, genetic variation, and the tumor microenvironment on ctDNA shedding. Based on these insights, we discuss emerging opportunities and challenges associated with nonshedder tumors and propose directions for future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.