Evidence map›Paper›PMID 41971786›Full record

ArticleFundamental research2026

A key heavy metal-binding protein orchestrates plant resistance against a geminivirus.

Hui Liu, Tao Hu, Fangfang Li, Yaqin Wang, Yuzhen Mei, Xueping Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hui LiuState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Tao HuState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Fangfang LiState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Yaqin WangState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Yuzhen MeiState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Xueping ZhouState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heavy metal-binding proteins (HMPs) are crucial for heavy metal ion transportation in plants, which is involved in plant nutrient absorption, morphogenesis, and immune responses. However, the molecular mechanism enabling the role of HMPs in plant defense in the presence of heavy metal ions has so far remained elusive. Here we show that NbHMP04 mediates host defenses against the geminivirus tomato yellow leaf curl China virus (TYLCCNV) by enhancing the stability of NbNPR1, and that this action is countered by a viral effector. NbHMP04-dependent host defenses against TYLCCNV are activated in the presence of copper ions, which enhances the interaction between NbHMP04 and NbNPR1, increasing NbNPR1 stability and up-regulating downstream gene expression. The TYLCCNB-encoded βC1 protein, however, interacts with NbHMP04 and induces NbHMP04 autophagic degradation to interrupt host immune responses. The TYLCCNV/TYLCCNB (βC1

Indexed as

AutophagyDefenseGeminivirusHeavy metal-binding proteinsTomato yellow leaf curl China virus

Identifiers

PMID41971786
PMCPMC13069656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.