Evidence map›Paper›PMID 41971757›Full record

ArticleBMJ oncology2025

Efficacy of nivolumab plus relatlimab versus BRAF/MEK inhibitors for first-line treatment of BRAF-mutant advanced melanoma: A matching-adjusted indirect comparison.

David M Miller, James W Smithy, Jennell Palaia, Divya Patel, Anthony Salvatore, David D'Adamo, Matthew Mattera, Zheng-Yi Zhou, Viviana Garcia-Horton, Ahmad A Tarhini

Abstract read
In one paragraph

Article in BMJ oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David M MillerDepartment of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9736-9119
James W SmithyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0003-3126-1193
Jennell PalaiaBristol Myers Squibb, Lawrenceville, New Jersey, USA.
Divya PatelBristol Myers Squibb, Lawrenceville, New Jersey, USA.
Anthony SalvatoreBristol Myers Squibb, Lawrenceville, New Jersey, USA.
David D'AdamoBristol Myers Squibb, Lawrenceville, New Jersey, USA.
Matthew MatteraAnalysis Group Inc, Boston, Massachusetts, USA.
Zheng-Yi ZhouAnalysis Group Inc, Boston, Massachusetts, USA.
Viviana Garcia-HortonAnalysis Group Inc, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0835-800X
Ahmad A TarhiniDepartments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background: Dual immuno-oncology (IO) therapy or BRAF/MEK inhibitor combinations are approved first-line (1L) treatment options for Methods: Patient-level data for NIVO+RELA from the RELATIVITY-047 trial ( Results: Conclusions: These MAICs suggest that 1L dual IO therapy with NIVO+RELA confers a long-term OS advantage in

Indexed as

ImmunotherapySkin cancer (malignant melanoma)

Identifiers

PMID41971757
PMCPMC13064201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.