ArticleEuropean heart journal. Digital health2026
Proteomic phenotyping with machine learning for cardiovascular outcomes in haemodialysis: insights from the AURORA trial.
Article in European heart journal. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: Cardiovascular (CV) trials have yielded neutral results in haemodialysis. A better understanding of patient profiles is needed to personalize treatment strategies in order to improve CV outcomes in this setting. This study sought to identify biological phenotypes based on proteomic data using machine learning approaches in patients undergoing haemodialysis. Methods and results: A clustering analysis using 253 plasma protein biomarkers was performed in 382 patients (machine learning derivation analysis) from the AURORA trial, which tested the effect of rosuvastatin on CV outcomes in patients on haemodialysis. A decision tree was subsequently constructed to predict cluster membership and assess its association with CV outcomes in another subset of the trial ( Conclusion: Using unsupervised machine learning on proteomic data, we identified four mechanistic biological phenotypes involving cytokine storm and TLRs signalling, inflammation and fibrosis. These biological phenotypes may contribute to CV prognosis and pave the way for personalized therapy in haemodialysis.
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