Evidence map›Paper›PMID 41971733›Full record

ArticleFrontiers in pediatrics2026

Role of

Alexander Bertuccioli, Annalisa Belli, Davide Sisti, Marco Bruno Luigi Rocchi, Chiara Maria Palazzi, Giordano Bruno Zonzini, Filippo Boccellari, Roberto Sacchetti, Francesco Di Pierro, Giuseppe Gregori

Abstract read
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander Bertuccioli *Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Annalisa Belli *Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Davide SistiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Marco Bruno Luigi RocchiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Chiara Maria PalazziMicrobiota International Clinical Society, Torino, Italy.
Giordano Bruno ZonziniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Filippo BoccellariPrimary Care Pediatricians, AUSL Piacenza, Piacenza, Italy.
Roberto SacchettiPrimary Care Pediatricians, AUSL Piacenza, Piacenza, Italy.
Francesco Di PierroMicrobiota International Clinical Society, Torino, Italy.
Giuseppe GregoriPrimary Care Pediatricians, AUSL Piacenza, Piacenza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antibiotic-associated diarrhea (AAD) is a common adverse effect of amoxicillin and amoxicillin/clavulanate therapy in children, primarily driven by antibiotic-induced dysbiosis, altered fermentation, and reduced production of short-chain fatty acids. Probiotics may help prevent AAD, but many strains are inhibited by these antibiotics. The present study specifically addresses the clinical impact of a single probiotic strain, Methods: We conducted a 15-day, prospective, single-center controlled study enrolling children between January 2021 and December 2022, recruited by three Italian pediatricians from the Lombardy region (Northern Italy), to evaluate the efficacy of Results: Among 426 enrolled children (284 supplemented, 142 controls), supplementation with Conclusions:

Indexed as

amoxicillinantibiotic-associated diarrheaBifidobacterium brevemicrobiotaprobiotics

Identifiers

PMID41971733
PMCPMC13061857

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.