Evidence map›Paper›PMID 41971710›Full record

ArticleInternational journal of endocrinology2026

Associations of Dietary and Circulating Choline and Glycine With Bone Mineral Density: UK Biobank Analyses With Mendelian Randomization.

Siyu Chen, Rui Lu, Yazhong Zhang, Yusheng Li, Xueqin Cao, Huilin Yang, Jun Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siyu ChenDepartment of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Medical Center of Soochow University, Suzhou, Jiangsu, China.
Rui LuDepartment of Radiology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China, njmu.edu.cn.
Yazhong ZhangDepartment of Orthopaedics, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China, xzmc.edu.cn.
Yusheng LiDepartment of Orthopaedics, Xiangya Hospital, National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-3404-0807
Xueqin CaoDepartment of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Medical Center of Soochow University, Suzhou, Jiangsu, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, scu.edu.tw.ORCID https://orcid.org/0000-0002-9459-7981
Jun LinDepartment of Orthopaedics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Medical Center of Soochow University, Suzhou, Jiangsu, China.ORCID https://orcid.org/0000-0002-8094-5826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Osteoporosis, characterized by reduced bone mass and compromised bone microarchitecture, significantly impacts public health, particularly among the elderly population. Although choline and its related metabolites are believed to influence bone health, their exact role and the effects of these metabolites on bone mineral density (BMD) remain unclear. Methods: We analyzed data from 18,769 UK Biobank (UKB) participants, excluding those with missing data or specific health conditions. All observational associations were assessed cross-sectionally at baseline. Choline intake was assessed using a self-administered 24-h dietary assessment, while circulating choline and related metabolites were quantified by nuclear magnetic resonance spectroscopy. BMD was measured using ultrasound densitometry. Linear regression models were used to assess the associations, adjusting for various covariates. Results: Overall, circulating choline levels demonstrated a borderline significant association with BMD ( Conclusions: Choline and glycine metabolism may play a role in bone metabolism, with choline showing particular effects in men and individuals with impaired renal function. Further research is necessary to better understand the underlying mechanisms and implications of these associations for osteoporosis risk in different populations.

Indexed as

causal inferencenutrient metabolitesobservational studyosteoporosisquantitative ultrasound

Identifiers

PMID41971710
PMCPMC13069184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.