ArticleFood science & nutrition2026
Ameliorative Effects of Lycopene and L-Carnitine on CCl
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Liver toxicity is a major health concern caused by pharmaceutical exposure, poisons like CCl4, or environmental contaminants. The CCl4-induced liver toxicity model is extensively used to study hepatic damage, such as oxidative stress and fibrosis. In current study, synergistic effect of natural compounds Lycopene (Lyc) and L-Carnitine (L-Car) possessing the antioxidant activity was assessed to mitigate the liver fibrosis induced by CCl4 in male rat model. CCl4 treated rats showed significant decrease in body weight (21.62% ± 0.83%) alongside elevated liver enzymes ALP (276 ± 6.62), AST (283 ± 4.53), ALT (138 ± 0.74), bilirubin (1.73 ± 0.74) and lactate dehydrogenase (LDH) an injury marker (0.778% ± 0.06%). After treatment of CCl4 induced fibrosis with Lyc + L-Car, significantly increased body weight of rats was observed (34.39% ± 0.77%). Liver enzymes also showed remarkable improvement after treatment with Lyc + L-Car (
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