ArticleFood science & nutrition2026
Is Acrylamide a Hidden Threat to Muscle Health? Integrative Evidence From Epidemiological and Mechanistic Investigations.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Acrylamide is an environmental toxicant widely found in processed foods and tobacco smoke. While its neurotoxic and carcinogenic effects are well established, its impact on skeletal muscle health remains poorly understood. This study aimed to investigate the association between acrylamide exposure and muscle mass using epidemiological data and to explore potential mechanisms through bioinformatic analyses. We analyzed data from 1443 adults participating in the 2013-2016 National Health and Nutrition Examination Survey. Hemoglobin adducts of acrylamide (HbAA), glycidamide (HbGA), and their ratio (HbGA/HbAA) were used as biomarkers of exposure. Multivariable linear regression models were applied to examine associations with muscle mass index, with results reported as beta coefficients and 95% confidence intervals (CIs). Restricted cubic spline (RCS) models assessed dose-response relationships. Mediation analyses explored the roles of potential mediators. Network-based bioinformatic analyses were performed to identify molecular targets and pathways. Higher HbAA levels were significantly associated with lower muscle mass index (
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