Evidence map›Paper›PMID 41971605›Full record

ArticleFood science & nutrition2026

Optimization of Phenolic and Flavonoid Extraction From Bee Bread Using Response Surface Methodology and Central Composite Design, and Evaluation of Antimicrobial Activity.

Nilay Keyvan, Muhammet Mükerrem Kaya, Melike Sultan Demirağ, Murat Bayezit, Hidayet Tutun, Hatice Ahu Kahraman, Erhan Keyvan

Abstract read
In one paragraph

Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nilay KeyvanDepartment of Food Hygiene and Technology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.
Muhammet Mükerrem KayaDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.
Melike Sultan DemirağDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.ORCID https://orcid.org/0000-0002-9391-2839
Murat BayezitDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.
Hidayet TutunDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.
Hatice Ahu KahramanDepartment of Food Hygiene and Technology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.
Erhan KeyvanDepartment of Food Hygiene and Technology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bee bread is a remarkable apicultural product recognized for its abundant proteins, minerals, vitamins, and phenolic compounds, which enhance its notable biological activity. This study aimed to optimize the extraction conditions to maximize the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity (DPPH) with conventional extraction of bee bread using response surface methodology (RSM) with Central Composite Design (CCD). The phenolic profile of the optimal extract was evaluated by high-performance liquid chromatography (HPLC). Antibacterial activity of the optimal extract was evaluated against

Indexed as

antimicrobial activityantioxidant activitybee breadresponse surface methodology

Identifiers

PMID41971605
PMCPMC13069165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.