Case Report: SS18::POU5F1-fused sarcoma with Flexner-Wintersteiner rosettes: a clinicopathological analysis of a rare tumor in the submandibular gland.

Zhaorong Niu, Guixiang Xiao, Yu Guo, Qin Xia, Jun Fan, Jun He, Danju Luo, Xiu Nie

Abstract readCase Reports

In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhaorong Niu *Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Guixiang Xiao *Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yu GuoDepartment of Pathology, First People's Hospital of Yibin City, Sichuan, Yibin, China.

Qin XiaPathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Jun FanPathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Jun HePathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Danju LuoPathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Xiu NiePathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SS18::POU5F1-fused sarcoma is an exceedingly rare malignant tumor, with only isolated case reports documented to date. We present the first reported case of SS18::POU5F1 fusion sarcoma occurring in the left submandibular gland of a middle-aged male patient. The tumor exhibited multiphasic differentiation, including epithelioid cells and undifferentiated round cell components, with focal evidence of neural differentiation and Flexner-Wintersteiner rosettes. It was characterized by the presence of a SS18::POU5F1 gene fusion. We provide a detailed description of the clinical features, histomorphology, immunophenotype, molecular characteristics, treatment, and prognosis of this case, discuss its differential diagnosis and potential pathogenesis, and include a comprehensive review of the relevant literature.

Indexed as

Flexner-Wintersteiner rosettesgene fusionneural differentiationSS18::POU5F1submandibular gland

Identifiers

PMID41971444

DOI10.3389/fonc.2026.1768229

PMCPMC13061702

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.