Evidence map›Paper›PMID 41971363›Full record

Trial reportFrontiers in nutrition2026

Using 6S-5-methyltetrahydrofolate instead of folic acid in prenatal multivitamin reduces unmetabolized folic acid concentrations in the mother-fetus dyad: a 24-week randomized controlled trial.

Fulvia Draicchio, Jeanette Hausser, Mastaneh Sharafi, Adeline Grier-Welch, Arianne Vance, Nima Alamdari, Itamar D Futterman, Scott Chudnoff, Olga Malysheva, Marie A Caudill and 2 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05673070 (Use of Ritual Prenatal Multivitamins to Improve Nutrition Status and Health Outcomes During Pregnancy), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05673070 nacompletednot on this map

Use of Ritual Prenatal Multivitamins to Improve Nutrition Status and Health Outcomes During Pregnancy

TypeinterventionalSponsorCity University of New YorkRan2023 to 2024Enrolled80ConditionsPregnancy Related, Nutrition, HealthyArmsRitual Epre Multivitamin-mineral supplement, control MVI
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fulvia DraicchioDepartment of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY, United States.
Jeanette HausserDepartment of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY, United States.
Mastaneh SharafiRitual, Los Angeles, CA, United States.
Adeline Grier-WelchRitual, Los Angeles, CA, United States.
Arianne VanceRitual, Los Angeles, CA, United States.
Nima AlamdariRitual, Los Angeles, CA, United States.
Itamar D FuttermanDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Maimonides Medical Center, Brooklyn, NY, United States.
Scott ChudnoffDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Maimonides Medical Center, Brooklyn, NY, United States.
Olga MalyshevaDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Marie A CaudillDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Isabelle HansonDepartment of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY, United States.
Xinyin JiangDepartment of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing number of prenatal multivitamin (MVI) products use 5-methyltetrahydrofolate (5-MTHF) in place of the synthetic folic acid (FA), because FA needs to be reduced to 5-MTHF for use in cellular methylation reactions and excess FA consumption can increase unmetabolized FA (UMFA) concentrations in circulation. However, the efficacy of 5-MTHF supplementation on maintaining maternal and fetal folate status in comparison to FA has not been sufficiently investigated. This study examined whether using 6S-5-MTHF instead of FA in a prenatal MVI affected total folate and UMFA status in maternal and fetal tissues. Eighty first-trimester pregnant participants were randomized to receive either a prenatal MVI containing 1,000 μg DFE of 6S-5-MTHF (MTHF-MVI group) or 1,330 μg DFE of FA (FA-MVI group) for 24 weeks ( Clinical trial registration: ClinicalTrials.gov, identifier: NCT05673070.

Indexed as

5-methyltetrahydrofolatefolic acidpregnancyprenatal multivitaminunmetabolized folic acid

Identifiers

PMID41971363
PMCPMC13062212

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.