Evidence map›Paper›PMID 41971229›Full record

ArticleKidney medicine2026

A Pilot Randomized Controlled Trial of Integrated Nephrology and Palliative Care Implemented at a Safety-Net Hospital.

Jennifer S Scherer, Sallie Yassin, Yuhe Xia, Keith S Goldfeld, Nina Caplin, Susan Cohen, Abraham A Brody, Joshua Chodosh, Angela McCarthy, Pragna Krishnamurthy and 3 more

Abstract read
In one paragraph

Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer S SchererDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Sallie YassinDivision of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY.
Yuhe XiaDivision of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY.
Keith S GoldfeldDivision of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY.
Nina CaplinDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Susan CohenDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Abraham A BrodyHartford Institute for Geriatric Nursing, New York University Rory Meyers College of Nursing, New York, NY.
Joshua ChodoshDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Angela McCarthyDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Pragna KrishnamurthyDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Haley GrossDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
Michal MelamedDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.
David M CharytanDepartment of Internal Medicine, New York University Grossman School of Medicine, New York, NY.

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Arline Faustin · 2020 to 2026
$28.4M
Supportive Care in Kidney Disease: Scope of Practice and Pilot Study of ImplementationK23DK125840 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHERER, JENNIFER S · 2020 to 2024
$962k
NIA NIH HHS P30 AG066512NIDDK NIH HHS K23 DK125840
6 · The paper itself

Abstract

Rationale & Objective: Randomized controlled trials (RCTs) show that integrated palliative care can improve symptoms compared with usual care in many serious illnesses, yet there are no comparable RCTs in chronic kidney disease (CKD). Study Design: We conducted a pilot feasibility RCT comparing kidney palliative care (KPC) integrated with CKD care with usual CKD care. Setting & Participants: English and Spanish speakers aged ≥18 years with CKD stage IV and V, or receiving dialysis, seen at an urban safety-net hospital. Exposures: Participants were randomized to usual CKD care or to usual CKD care plus 6-monthly ambulatory KPC visits. Outcomes: Primary outcomes were feasibility of recruitment, retention, intervention delivery, and data collection. Secondary outcomes included change in symptom burden at 6 months, measured by the Integrated Palliative Outcome Scale (IPOS)-Renal (lower scores represent lower burden), quality of life measured by the Kidney Disease Quality of Life 36-item survey, and engagement in advance care planning. Analytical Approach: Feasibility outcomes are reported as proportions and clinical outcomes as descriptive summaries of change in scores. Results: Of the 146 people approached, 84 (56%) consented, 75 (89%) were randomized, and 57 (76%) completed the trial. 56% of participants were Hispanic and 32% were Black, with 49% on Medicaid and 13% uninsured. The mean age of participants was 61 years, and 31% were receiving dialysis. A mean of 4-6 intervention visits was attended. At 6 months, the intervention group had a 4.1-point decrease in IPOS score (standard deviation 13.4), whereas the mean IPOS score of the control group increased by 0.6 points (standard deviation 7.8) from baseline. Limitations: Small sample size and limited number of providers to assess generalizability. Conclusions: We demonstrate the feasibility of an RCT comparing integrated KPC with usual CKD care in a safety-net hospital. Although this study was not powered to detect significance in change of clinical outcomes, our findings suggest that there is value in testing KPC in efficacy trials and that these are feasible.

Indexed as

chronic kidney diseasefeasibilityPalliative carepilotrandomized controlled trialsafety net

Identifiers

PMID41971229
PMCPMC13069507

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.