Evidence map›Paper›PMID 41971225›Full record

ArticleDepression and anxiety2026

Symptom Structure of Depression and Anxiety in Mothers Following Child Loss: A Network and Bayesian Graph Analysis.

Firoj Al-Mamun, Mohammed A Mamun, Moneerah Mohammad Almerab, Suzanne Holroyd, David Gozal, Mohammad Muhit

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Article in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

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6 authors.

Firoj Al-MamunDepartment of Public Health, University of South Asia, Dhaka, 1348, Bangladesh.ORCID 0000-0003-4611-9624
Mohammed A MamunDepartment of Public Health, University of South Asia, Dhaka, 1348, Bangladesh.ORCID 0000-0002-1728-8966
Moneerah Mohammad AlmerabDepartment of Psychology, College of Education and Human Development, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia, pnu.edu.sa.ORCID 0000-0003-4987-0309
Suzanne HolroydDeptartment of Psychiatry and Behavioral Medicine, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, 25701, West Virginia, USA, marshall.edu.ORCID 0000-0002-3610-0607
David GozalOffice of the Dean and Department of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, 25701, West Virginia, USA, marshall.edu.ORCID 0000-0001-8195-6036
Mohammad MuhitDepartment of Public Health, University of South Asia, Dhaka, 1348, Bangladesh.ORCID 0000-0002-3244-957X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bereavement, especially following the loss of a child, is a profoundly distressing life event associated with heightened risks of depression and anxiety. However, limited evidence exists on the symptom-level structure and statistical interrelations of these conditions among bereaved individuals, particularly in low- and middle-income countries (LMICs). Methods: Using nationally representative data from the 2022 Bangladesh Demographic and Health Survey (BDHS), we identified 2276 bereaved mothers. We applied psychological network analysis to estimate the partial correlation network structure of nine-item Patient Health Questionnaire (PHQ-9) depressive and seven-item Generalized Anxiety Questionnaire (GAD-7) anxiety symptoms. Centrality, predictability, and bridge metrics were computed. Network comparison tests (NCTs) assessed structural invariance across bereavement subgroups. Bayesian directed acyclic graphs (DAGs) were used to explore conditional dependency patterns and probabilistic edge orientations among symptoms. Results: The prevalence of probable major depressive disorder (MDD) was 6.69% (95% CI: 5.52-7.86). Prevalence estimates were comparable by bereavement recency, with overlapping confidence intervals among mothers bereaved within the past 3 years (5.34%, 95% CI: 3.06-9.15) and those bereaved more than 3 years earlier (6.83%, 95% CI: 5.69-8.19). The symptom network revealed interconnected domains corresponding to anxiety and depression symptoms. Trouble relaxing and psychomotor disturbance showed the highest strength centrality, while suicidal ideation exhibited the highest predictability in the network. Bridge centrality analysis identified feeling afraid, sadness, irritability, and psychomotor disturbance as the strongest cross-domain connectors linking anxiety and depression symptoms. Bayesian DAG analysis indicated strong conditional dependencies among worry-related anxiety symptoms, while psychomotor disturbance showed a strong conditional association with suicidal ideation. Conclusions: This study offers novel symptom-level insights into bereavement-related anxiety and depression among mothers in Bangladesh. The observed symptom patterns are consistent with enduring depressive and anxiety symptoms rather than acute grief alone. Symptom-focused approaches targeting central and bridge symptoms may support more efficient screening and scalable intervention strategies in bereaved populations.

Indexed as

AnxietyBereavementDepressionMajor Depressive DisorderMothersAdultBangladeshBayes TheoremFemaleGeneralized Anxiety DisorderHumansMiddle AgedPrevalenceYoung Adultanxietybereavementdepressiondirected acyclic graph (DAG)maternal mental healthsymptom network analysis

Identifiers

PMID41971225
PMCPMC13062755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.