ReviewRomanian journal of ophthalmology
Study of Correlation of Severity of Diabetic Retinopathy with Corneal Thickness and Endothelial Parameter Changes in Diabetic Patients.
Review in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Corneal endothelial changes in type 2 diabetes mellitus: a systematic review and meta-analysis with subgroup comparisons by diabetic retinopathy status and disease duration.Frontiers in endocrinology · 2026Pooled it
- Sleep patterns, physical activity and glycemic control in newly diagnosed type 2 diabetes patients from a joint perspective: a cross-sectional study.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Corneal endothelium plays an essential role in maintaining corneal transparency and hydration. Conditions or events causing endothelial cell loss beyond the threshold value can lead to loss of corneal transparency. Our study aimed to assess the effects of duration of Type 2 Diabetes Mellitus and diabetic retinopathy (DR) severity on the corneal endothelium using non-contact specular microscopy. Materials and methods: A prospective study was conducted on 200 eyes of diabetic patients and their age-matched controls. On their first visit, a detailed history including diabetic status, duration of diabetes, and previous eye surgeries was taken. A comprehensive ophthalmic evaluation was done. Corneal endothelial parameters like Central Corneal Thickness (CCT), Endothelial Cell Density (ECD), Coefficient of Variation (CV), and hexagonality were obtained using a non-contact Specular microscope. Data was tabulated and analysed using appropriate statistical tests, and a "p" value of less than 0.05 was considered statistically significant. Results: Endothelial cell hexagonality and duration of diabetes were found to be significantly correlated (p value of 0.001 using an independent t-test), indicating that a longer duration of diabetes causes morphological changes in the corneal endothelium. Other parameters, such as CCT, CV, and ECD, did not correlate significantly with HbA1c levels, diabetes duration, or DR severity. Discussion: In our study, we evaluated all endothelial parameters and correlated them with the duration of DM (<10 yrs and >10 yrs). Average ECD, CV, and HEX in the two subgroups were 2494.3 ± 405.2 cells/mm Interpretation and Conclusion: Our findings indicate that corneal endothelial cells undergo morphological changes with increasing duration of Diabetes. The findings of this study add to the literature on the effects of Diabetes on endothelial health, which might help improve the management of these patients. Future longitudinal studies with larger, diverse cohorts are recommended to validate these associations and explore therapeutic interventions to preserve corneal health in diabetes.
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