ArticleReproductive medicine and biology
Uterine Endometrial Microbiome and Chronic Endometritis in Relation to Anti-β2-Glycoprotein I (β2GPI)/Human Leukocyte Antigen (HLA)-DR Autoantibodies in Women With Recurrent Implantation Failure and Recurrent Pregnancy Loss: A Cross-Sectional Study.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anti-β2GPI/HLA-DR autoantibodies may be involved in recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL). We examined their association with the endometrial microbiome and chronic endometritis (CE). Methods: In this cross-sectional study, 141 women (54 RIF, 87 RPL) were enrolled. Serum anti-β2GPI/HLA-DR positivity was defined using 99th/95th percentile cut-offs. Endometrial microbiome was assessed by 16S rRNA sequencing, focusing on reproductive-failure-related species ( Results: In RIF, antibody-positive women more frequently had Conclusion: Anti-β2GPI/HLA-DR antibody positivity was associated with endometrial dysbiosis and may serve as a biomarker of abnormal intrauterine environment in reproductive failure.
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