Evidence map›Paper›PMID 41971183›Full record

ArticleInternational journal of cardiology. Heart & vasculature2026

D-dimer levels and outcomes in heart failure with mildly reduced ejection fraction.

Finn Kronberg, Tobias Schupp, Michael Behnes, Michelle Goertz, Marielen Reinhardt, Noah Abel, Alexander Schmitt, Felix Lau, Mohammad Abumayyaleh, Thomas Bertsch and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Finn KronbergDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Tobias SchuppDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Michael BehnesDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Michelle GoertzDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Marielen ReinhardtDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Noah AbelDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Alexander SchmittDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Felix LauDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Mohammad AbumayyalehDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Thomas BertschInstitute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany.
Ibrahim AkinDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
Kathrin WeidnerDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The study investigates the influence of D-dimer levels on the prognosis of patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). Background: The prognostic impact of D-dimer levels has not yet been investigated in patients with HFmrEF. Methods: We retrospectively included consecutive patients with HFmrEF at one institution from 2016 to 2022. Patients were divided in quartiles according to their D-dimer levels, further sub-analyses were performed after excluding patients with conditions associated with increased D-dimer levels. The primary endpoint was all-cause mortality at 30 months (median follow-up), key secondary endpoint was the risk of heart failure (HF)-related rehospitalization. Results: In total, 1126 patients with HFmrEF were included with a median D-dimer level of 0.87 µg/mL (interquartile range 0.42-2.19 µg/mL). Higher D-dimer levels were associated with an increased risk of all-cause mortality (Q4 vs. Q1: hazard ratio (HR) 6.817; 95% confidence interval (95% CI) 4.401-10.561, p = 0.001), which was still observed after multivariable adjustment (Q4 vs. Q1: adjusted (a)HR 3.228; 95% CI 1.901-5.479; p = 0.001). This association was still observed after excluding patients with conditions associated with elevated D-dimer levels. Conclusion: Elevated D-dimer levels were independently associated with a higher risk of all-cause mortality in HFmrEF patients.

Indexed as

BiomarkersD-dimerHeart failure with mildly reduced ejection fractionHFmrEF

Identifiers

PMID41971183
PMCPMC13062528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.