ArticleTranslational andrology and urology2026
Evaluation of collagen membrane grafting in managing Peyronie's disease and penile curvature: a pilot study.
Article in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Peyronie's disease (PD), also known as penile fibromatosis, predominantly impacts middle-aged males between the ages of 55 and 65 years, with an incidence of from 3.2% to 8.9%. This exploratory study evaluated short-term outcomes following surgical correction using collagen membrane transplantation in a small cohort of patients. We selected a bovine collagen membrane for its 'off-the-shelf' availability and guided tissue regeneration (GTR) properties to avoid donor-site morbidity. The GTR membrane acts as a barrier, mechanically preventing the rapid ingrowth of fibroblasts from the surrounding tissue, thereby favoring organized tunical repair. This study aimed to evaluate the feasibility, safety, and short-term outcomes of surgical correction using a bovine collagen membrane (BME-10X) for tunical repair in patients with PD. Methods: Twenty patients (mean age 55 years, range 42-66 years) diagnosed with PD underwent collagen membrane grafting. Outcomes were assessed preoperatively and at a 6-month postoperative follow-up using the International Index of Erectile Function-5 (IIEF-5), Rigiscan monitoring (mean glanular erection rigidity), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS). Results: In this initial short-term evaluation of 20 patients, collagen membrane grafting suggested feasibility and was associated with improvements in penile deformity, IIEF-5 scores, glanular rigidity, SAS, and SDS scores compared to baseline. Key limitations include the small sample size (n=20) and short follow-up period (6 months), which preclude definitive conclusions regarding long-term efficacy, durability, recurrence risk, and broader applicability. Conclusions: This preliminary study suggests that collagen membrane transplantation may offer a potential surgical approach for the short-term management of penile curvature in PD, with associated improvements in erectile function and patient-reported anxiety and depression symptoms in this small cohort. However, these initial findings require rigorous validation in larger, long-term studies to confirm efficacy, safety profile, and sustained benefit.
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