Evidence map›Paper›PMID 41971075›Full record

ArticleFrontiers in pharmacology2026

Glabrol-an impurity in licorice extract-causes toxicity in muscle, bone, and immune tissues through activation of the AP-1 signaling pathway.

Chenyang Jiang, Xinshu Feng, Mingyu Qi, Shaojuan Wu, Qiuyu Wang, Yawen Zhou, Xiaoshan Zheng, Zhuogui Liang, Jianhua Tan, Yudong Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenyang JiangGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Department of Medical Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Xinshu FengGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Department of Medical Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Mingyu QiGuangzhou Shanhai Biotechnology Co., Ltd., Guangzhou, China.
Shaojuan WuGuangzhou Tongjun Pharmaceutical Technology Co., Ltd., Guangzhou, China.
Qiuyu WangGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Department of Medical Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yawen ZhouDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaoshan ZhengGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Department of Medical Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Zhuogui LiangGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), South China University of Technology, Guangzhou, China.
Jianhua TanGuangzhou Quality Supervision and Testing Institute, Guangzhou, China.
Yudong ZhangSchool of Light Chemical Engineering, Guangdong University of Technology, Guangzhou, China.
Qingquan GuoSchool of Light Chemical Engineering, Guangdong University of Technology, Guangzhou, China.
Haishan ZhaoGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Department of Medical Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Licorice (

Indexed as

AP-1 signaling pathwaybiological effectsglabrollicoricetoxicity

Identifiers

PMID41971075
PMCPMC13066261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.