Evidence map›Paper›PMID 41971067›Full record

ArticleMolecular therapy. Nucleic acids2026

Time- and spatially resolved LNA delivery via thermally controlled SPION technology.

Franziska Kenneweg, Katharina Hempel, Lukas Philipp Joachim Höhne, Gerald Dräger, Jonas Blume, Thilo Viereck, Anastasia Stohwasser, Sonja Groß, Gwen Büchler, Karina Jansen and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Franziska KennewegInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Katharina HempelInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Lukas Philipp Joachim HöhneInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Gerald DrägerInstitute of Organic Chemistry, Leibniz University Hannover, 30167 Hannover, Germany.
Jonas BlumeInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Thilo ViereckInstitute for Electrical Measurement Science and Fundamental Electrical Engineering (emg), TU Braunschweig, 38106 Braunschweig, Germany.
Anastasia StohwasserInstitute of Organic Chemistry, Leibniz University Hannover, 30167 Hannover, Germany.
Sonja GroßInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Gwen BüchlerInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Karina JansenInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Malte JuchemInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Christian BärInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Angelika PfanneInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Annette JustInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Sabrina ThumInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Anika GietzInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Andreas KirschningInstitute of Organic Chemistry, Leibniz University Hannover, 30167 Hannover, Germany.
Thomas ThumInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted RNA delivery with precise spatial and temporal control marks a significant advancement in therapeutic development, offering the potential to reduce drug dosages while minimizing off-target effects. In this study, we present a novel platform that employs superparamagnetic iron oxide nanoparticles (SPIONs) for externally controlled, thermally triggered, organ-specific locked nucleic acid (LNA) release. Our platform technology leverages a newly designed thermosensitive conjugate, based on a thermosensitive linker system that utilizes the thermal sensitivity of the

Indexed as

drug conjugateshyperthermialinkermicroRNAmiR-21MT: Delivery Strategiesnanoparticles

Identifiers

PMID41971067
PMCPMC13068855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.