ReviewMolecular therapy. Nucleic acids2026
Modulating G-quadruplexes for therapeutic intervention: Structural diversity, stability, and emerging nucleic-acid-based strategies.
Review in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Aptamer-Based Fluorescent Biosensors for Kanamycin Detection in Food Systems: Design Strategies, Sensing Mechanisms, and Practical Applications.Foods (Basel, Switzerland) · 2026Review
- Variation and selection at predicted G-quadruplexes across the human pangenome.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. The G4s are formed by planar G-tetrads and stabilized by monovalent metal cations such as potassium or sodium. The structural diversity of G4s arises from differences in strand orientation, loop arrangement, and molecularity, leading to multiple topologies. The length of guanine tracts (G-tracts) and the number of strands involved further influence G4 folding, stability, and biological function. G-quadruplexes are commonly found in key genomic regions such as telomeres, promoters, and untranslated regions, where they play important roles in regulating fundamental biological processes, including replication, transcription, and translation. In this review, we summarize the molecular factors influencing G4 formation and stability. We also discuss recent advances in therapeutic strategies for targeting G-quadruplexes. Particular attention is given to antisense oligonucleotides (ASOs), ASO-ligand conjugates, peptide nucleic acids (PNAs), and PNA-conjugates as chemical tools for selective G4 recognition and modulation. We highlight the potential of nucleic-acid-based approaches for molecular therapeutics, including applications in anticancer and antiviral treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.