Evidence map›Paper›PMID 41971061›Full record

ArticleFrontiers in surgery2026

Case Report: First case of synchronous androgen receptor-positive salivary duct carcinoma and prostate adenocarcinoma.

Sofia Kourou, Louis Jansen, Lisa Nachtsheim, Julia van de Loo, Christoph Arolt, Lena Hieggelke, Alexander Quaas, Jens Peter Klussmann, Marcel Mayer

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sofia KourouDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Louis JansenDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Lisa NachtsheimDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Julia van de LooDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Christoph AroltInstitute of Pathology, Medical Faculty, Medical Faculty, University of Cologne, Cologne, Germany.
Lena HieggelkeInstitute of Pathology, Medical Faculty, Medical Faculty, University of Cologne, Cologne, Germany.
Alexander QuaasInstitute of Pathology, Medical Faculty, Medical Faculty, University of Cologne, Cologne, Germany.
Jens Peter KlussmannDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Marcel MayerDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The synchronous occurrence of two androgen receptor-positive (AR+) malignancies with overlapping metastatic patterns is exceedingly rare and poses significant diagnostic and therapeutic challenges. Salivary duct carcinoma (SDC) is an aggressive AR + tumor with a high propensity for early metastasis, whereas low-risk prostate adenocarcinomas (PCa) are often indolent. We report the first case of a synchronous SDC of the right parotid gland and a low-grade PCa, where the origin of osseous metastatic spread was initially unknown. Case presentation: A 65-year-old male patient presented with progressive right-sided facial palsy and multiple osseous lesions. Initial histopathological assessment of the parotid mass and assignment of the metastases remained inconclusive. After performing a prostate-specific membrane antigen-positron emission tomography/computed tomography (PSMA-PET-CT) scan, a low-grade prostate adenocarcinoma (PCa) (Gleason 3 + 3) was diagnosed. Further pathological and imaging evaluation revealed an AR+, HER2-low, CK7-positive SDC. The extensive skeletal metastases were attributed to the SDC. Conclusion: This case shows the diagnostic complexity of synchronous AR + malignancies with overlapping metastatic profiles and emphasizes the need for integrated clinical, radiological, and pathological assessment to ensure optimal patient management. It highlights the need to biopsy metastatic bone lesions in cases of SDC-especially in older men-to rule out osseous metastases from more frequent carcinomas such as PCa.

Indexed as

androgen receptorhead and neck carcinomametastasisprostate carcinomasalivary duct carcinomatargeted therapy

Identifiers

PMID41971061
PMCPMC13062289

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