ArticleBrain communications2026
Prolonged focal impaired consciousness seizures: a biomarker of drug resistance in patients with epilepsy.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The study aimed to explore whether Prolonged Focal Impaired Consciousness seizures (pFIC) predict drug resistance in patients with epilepsy and to identify the optimal seizure duration threshold for predicting this outcome. We registered all patients with epilepsy who were consecutively admitted to the Comprehensive Epilepsy Unit for long-term video-electroencephalogram (VEEG) monitoring at the First Affiliated Hospital of Sun Yat-sen University from January 2013 to December 2023. The database consisted of demographic information, clinical characteristics and electroencephalogram records. We evaluated the predictive performance of the recorded longest duration of Focal Impaired Consciousness seizures (FIC) through Receiver Operating Characteristic (ROC) analysis in patients with drug-resistant epilepsy (DRE). We developed and validated the optimal prognostic cut point for FIC longest duration for predicting DRE outcome using the Youden index. We compared the clinical and electroencephalographic characteristics between those with seizure duration shorter or longer than the cut point and developed a DRE prediction model. Within 18 924 patients admitted in the registration database, 490 patients who experienced FIC during VEEG monitoring were enrolled in this study, among whom 122 (24.9%) were diagnosed with DRE. The optimal cutoff point for the longest duration of FIC was 3 min (Youden index of 0.111, sensitivity of 47.5%, and specificity of 63.6%). 192 (39.2%) patients' longest FIC duration was greater than or equal to 3 min, and 298 (60.8%) patients' longest FIC duration for <3 min. There were more DRE patients in pFIC duration group than in shorter FIC group (21.5% versus 30.2%,
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