ArticleInternational journal of general medicine2026
Humoral Immune Response to SARS-CoV-2 in Children with Idiopathic Nephrotic Syndrome: A Cross-Sectional Exploratory Study.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Children with idiopathic nephrotic syndrome face a high risk of infections due to an abnormal antibody response. This study aims to evaluate the humoral immunity in children with nephrotic syndrome against SARS-CoV-2. Methods: This cross-sectional study assessed anti-spike SARS-CoV-2 IgG levels in children with nephrotic syndrome and compared them with those in the control group. Data on COVID-19 exposure and vaccination were collected from caregivers. Statistical analyses were performed using appropriate parametric and non-parametric tests, with a significance level set at p < 0.05. Results: Thirty-five children (10 with nephrotic syndrome and 25 controls) were enrolled. Seropositivity rates were 60% in children with nephrotic syndrome versus 32% in controls (p = 0.15). Mean antibody levels were comparable between groups (0.74 ± 0.68 vs 0.89 ± 1.24, p = 0.64), with no statistically significant differences observed in children receiving steroid therapy. Conclusion: The humoral response to COVID-19 was similar in children with idiopathic nephrotic syndrome compared to control children, suggesting that routine vaccination schedules remain appropriate in this group. These findings suggest preserved antibody responses in this population; however, due to the exploratory nature of this study, larger studies are needed before clinical recommendations can be modified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.