Evidence map›Paper›PMID 41971018›Full record

ArticleTransboundary and emerging diseases2026

Genetic Characterization and Pathogenicity of a Triple-Reassortant H1N1 Swine Influenza Virus Isolated in Guangdong.

Benkuan Li, Yu Wu, Yi Song, Hui Guo, Guangrun Qin, Limiao Lin, Haishen Zhao, Bohua Ren, Qunhui Li, Lianxiang Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benkuan LiSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China, fosu.edu.cn.ORCID https://orcid.org/0009-0004-9347-7074
Yu WuWen's Food Group, Yunfu, 527400, China.ORCID https://orcid.org/0009-0008-6126-7602
Yi SongCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, scau.edu.cn.
Hui GuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, scau.edu.cn.
Guangrun QinCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, scau.edu.cn.
Limiao LinWen's Food Group, Yunfu, 527400, China.
Haishen ZhaoWen's Food Group, Yunfu, 527400, China.
Bohua RenWen's Food Group, Yunfu, 527400, China.
Qunhui LiWen's Food Group, Yunfu, 527400, China.
Lianxiang WangSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China, fosu.edu.cn.ORCID https://orcid.org/0009-0005-7473-0406
Huihua ZhangSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China, fosu.edu.cn.ORCID https://orcid.org/0000-0001-7785-3720

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An H1N1 subtype swine influenza virus (SIV) was isolated from nasal swabs collected from pigs with suspected swine influenza (SI) on a farm in Guangdong, China. The virus, designated A/Swine/Guangdong/JJK/2025(H1N1) (abbreviated as JJK), underwent whole-genome sequencing and phylogenetic analysis, which confirmed that it is a triple-reassortant strain. The hemagglutination (HA) and neuraminidase (NA) genes originated from the Eurasian avian-like (EA) H1N1 lineage, the internal genes (PB2, PB1, PA, NP, and M) originated from the 2009 pandemic H1N1 lineage, and the NS gene originated from the triple-reassortant H1N2 lineage. Each of the eight gene segments showed the highest homology to a different reference virus. Analysis of key amino acid substitutions identified multiple mutations in proteins, such as HA, PB2, and PB1, that are associated with enhanced mammalian adaptation, increased virulence, and modulation of host immune responses. Animal pathogenicity testing demonstrated that JJK was significantly pathogenic in female BALB/c mice, with an MLD

Indexed as

Influenza A Virus, H1N1 SubtypeOrthomyxoviridae InfectionsReassortant VirusesSwine DiseasesAnimalsChinaFemaleMiceMice, Inbred BALB CPhylogenySwineVirulenceH1N1molecular characterizationpathogenicityphylogenetic analysisswine influenza virus

Identifiers

PMID41971018
PMCPMC13069155

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.