ArticleFrontiers in endocrinology2026
The role of the lactate dehydrogenase-to-albumin ratio in predicting renal prognosis in Chinese IgA nephropathy patients: a retrospective cohort study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Background: Immunoglobulin A nephropathy (IgAN) is one of the most common types of primary glomerulonephritis and is an important cause of end-stage renal disease (ESRD) worldwide. Inflammation has been shown to be associated with its basic pathogenesis. The lactate dehydrogenase-to-albumin ratio (LAR), a novel marker of inflammation and nutritional status, has been studied in various diseases. However, whether the LAR also plays a critical role in Chinese patients with IgAN remains unknown. Thus, we conducted this retrospective study to evaluate the role of the LAR in predicting clinicopathologic changes and disease prognosis in IgAN patients. Methods: A total of 1,276 patients with biopsy-proven IgAN were enrolled in this study. The patients were grouped into a high LAR group (LAR ≥4.05, Results: IgAN patients with a high LAR had an increased incidence of anemia and increased levels of proteinuria, serum creatinine, and serum lipids. Multivariate Cox regression analysis indicated that a high LAR was an independent risk factor for IgAN even after adjustment for important clinicopathological parameters (HR = 1.844, 95% CI = 1.138-2.988, Conclusion: An elevated LAR affects renal progression and prognosis in patients with IgAN and could be a novel marker for the management of IgAN patients in the future.
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