ReviewFrontiers in cell and developmental biology2026
Chondrocytes
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Auricular cartilage defects, whether congenital or acquired, present a significant reconstructive challenge. Autologous chondrocytes implantation remains the clinical gold standard but is limited by donor-site morbidity, limited cell availability, and dedifferentiation during expansion. Cartilage stem/progenitor cells (CSPCs) have emerged as a promising alternative, yet their comparative properties remain underexplored. Methods: A comprehensive literature review was conducted across PubMed, MEDLINE, Cochrane, and Web of Science databases up to 2026, utilizing keywords such as chondrocytes, chondroprogenitors, Cartilage stem/progenitor cells, CSPCs, auricular cartilage, ear reconstruction and tissue engineering. Results: Chondrocytes exhibit robust matrix synthesis but suffer from dedifferentiation and limited proliferation. CSPCs demonstrate superior self-renewal and immunomodulatory properties, yet face challenges of hypertrophic differentiation and inferior tissue elasticity. Co-culture and scaffold-based strategies have been employed to enhance the functionality of both cell types in engineered constructs. Conclusion: Both chondrocytes and CSPCs present distinct advantages and limitations for auricular cartilage repair. Future strategies should aim to combine their strengths, such as the functional specificity of chondrocytes and the expandability of CSPCs, to develop more effective and clinically feasible tissue-engineered constructs for ear reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.