ArticleFrontiers in cell and developmental biology2026
Effects of leukoreduction and storage duration on whole blood hemostatic function: a prospective
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Whole blood (WB) resuscitation is a critical component of trauma care. Leukoreduction (LR) is commonly employed to mitigate transfusion-related risks. We aimed to understand the effects of LR on the functionality and metabolism of various components in refrigerated WB and provide new strategies for WB application in trauma treatment. Methods: Ten bags of WB (400 mL ± 10%) were split into paired samples with and without LR and stored at 4°C ± 2 °C for 35 days. Storage-lesion tests were performed every 7 days from the day of blood collection. Descriptive heatmaps and weighted gene co-expression network analysis (WGCNA) were used to characterize global patterns of indicator change, while exploratory mediation models and penalized regression (LASSO) were applied to investigate pathways and rank variables associated with clot strength. Results: Descriptive heatmaps and exploratory WGCNA analyses suggested two distinct temporal patterns: platelet-related and viscoelastic indicators decreased progressively, whereas metabolic, hemolytic, and electrolyte indicators increased over time. On Day 0 (immediately after leukoreduction), leukoreduced whole blood (LR-WB) had a markedly lower platelet count than paired nonleukoreduced whole blood group (NLR-WB) (23.40 ± 2.00 vs. 185.20 ± 2.93 *10 Conclusion: LR was associated with early platelet-driven hemostatic impairment, and storage time appeared to progressively shift injury mechanisms toward RBC membrane instability, hemolysis, and metabolic stress. RBCs' PS exposure and FHb can serve as candidate indicators associated with clot strength.
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