Evidence map›Paper›PMID 41970952›Full record

ArticleFrontiers in cell and developmental biology2026

Histone methyltransferase G9a crosstalks with H3K36 histone methyltransferases NSD3 and SETD2 to mediate gene activation.

Arunim Shah, Chandra Prakash Chaturvedi, Kulwant Singh, Shobhita Katiyar, Akhilesh Sharma

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In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Arunim ShahStem Cell Research Center, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Chandra Prakash ChaturvediStem Cell Research Center, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Kulwant SinghStem Cell Research Center, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Shobhita KatiyarStem Cell Research Center, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Akhilesh SharmaStem Cell Research Center, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The euchromatic histone methyltransferase G9a/KMT1C/EHMT-II functions as a corepressor and a coactivator of transcription, depending upon its association with distinct protein complexes. While the mechanisms of G9a-mediated repression are well understood, the molecular mechanism of G9a-mediated activation remains elusive. In the present study, we report that the coactivator function of G9a involves its association with H3K36 histone methyltransferases, including NSD3/KMT3F/WHSC1L1 and SETD2/KMT3A. Functionally, we demonstrate that the association of G9a with NSD3 and SETD2 is necessary for activating G9a target adult

Indexed as

coactivatorG9aNSD3SETD2β-globin locus

Identifiers

PMID41970952
PMCPMC13062286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.