ArticleACS omega2026
Search for Inhibitors against Inflammatory Responses of Microglia in a Meroterpenoid Library Constructed by Synthetic-Biological Manipulation of Biosynthetic Pathways.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia are the resident immune cells of the central nervous system. Activation-induced proinflammatory responses of microglia are associated with various neurodegenerative diseases, and therefore, inhibitors against microglial inflammatory responses are promising candidates for the treatment of those diseases as well as efficient tools to investigate the involvement of microglia in the pathologies. Here, we focused on meroterpenoids (MPs), which are hybrid compounds of a terpenoid and a nonterpenoid moiety such as a polyketide, phenol, alkaloid, or amino acid. We constructed a structurally diverse library of MPs by expressing combinations of enzymes catalyzing various biosynthetic steps, including polyketide synthesis, prenyl transfer, prenyl chain epoxidation, terpene cyclization, and postcyclization tailoring reactions, in
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Registered trials
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