Evidence map›Paper›PMID 41970842›Full record

ArticleACS omega2026

Chelator Conjugation Chemistry Matters: Squaramide Linker Enhances Tumor Contrast in

Jelena Saliën, Sam Floru, Michiel Van Hove, Tessa De Pauw, Romane Vizier, Michael Claron, Jessica Bridoux, Victor Goncalves, Franck Denat, Sophie Hernot

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jelena SaliënBrussels Health Campus/Faculty of Medicine and Pharmacy, Molecular Imaging and Therapy (MITH), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels 1090, Belgium.ORCID https://orcid.org/0000-0001-6968-5835
Sam FloruBrussels Health Campus/Faculty of Medicine and Pharmacy, Molecular Imaging and Therapy (MITH), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels 1090, Belgium.ORCID https://orcid.org/0000-0002-2385-5947
Michiel Van HoveBrussels Health Campus/Faculty of Medicine and Pharmacy, Molecular Imaging and Therapy (MITH), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels 1090, Belgium.
Tessa De PauwBrussels Health Campus/Faculty of Medicine and Pharmacy, Molecular Imaging and Therapy (MITH), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels 1090, Belgium.ORCID https://orcid.org/0000-0001-7359-1751
Romane VizierUniversité Bourgogne Europe, CNRS, Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB, UMR CNRS 6302), 9 avenue Alain Savary, Dijon Cedex 21078, France.ORCID https://orcid.org/0000-0001-6548-4040
Michael ClaronUniversité Bourgogne Europe, CNRS, Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB, UMR CNRS 6302), 9 avenue Alain Savary, Dijon Cedex 21078, France.
Jessica BridouxBrussels Health Campus/Faculty of Medicine and Pharmacy, Molecular Imaging and Therapy (MITH), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels 1090, Belgium.ORCID https://orcid.org/0000-0002-8895-9763
Victor GoncalvesUniversité Bourgogne Europe, CNRS, Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB, UMR CNRS 6302), 9 avenue Alain Savary, Dijon Cedex 21078, France.ORCID https://orcid.org/0000-0001-9854-4409
Franck DenatUniversité Bourgogne Europe, CNRS, Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB, UMR CNRS 6302), 9 avenue Alain Savary, Dijon Cedex 21078, France.ORCID https://orcid.org/0000-0002-9652-4006
Sophie HernotBrussels Health Campus/Faculty of Medicine and Pharmacy, Molecular Imaging and Therapy (MITH), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels 1090, Belgium.ORCID https://orcid.org/0000-0002-8739-6137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complexation of radiometals by chelators allows for convenient radiolabeling of molecules of interest for the preparation of radiopharmaceuticals. In the chelator family, triazacyclononane (TACN)-based macrocycles have been used ubiquitously over the last 40 years, and many bifunctional derivatives have been developed. Despite this diversity, researchers commonly make their chelator selection based on practical factors like (commercial) availability and compatibility with the desired radionuclide, acknowledging that these considerations often outweigh achieving ideal

Identifiers

PMID41970842
PMCPMC13063190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.