Evidence map›Paper›PMID 41970838›Full record

ArticleACS omega2026

Microwave-Assisted Synthesis and Enzyme Stabilization Study of

Lee S Cantrell, Bret DeGraaff, Jack Hostetler, Rachel Koentopp, Karna Terpstra, Sarah Weissinger, Sarah M Zeitler, Trisha A Russell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lee S CantrellDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Bret DeGraaffDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Jack HostetlerDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Rachel KoentoppDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Karna TerpstraDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Sarah WeissingerDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Sarah M ZeitlerDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.
Trisha A RussellDepartment of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, Washington 99251, United States.ORCID https://orcid.org/0000-0003-1116-5313

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the lysosomal enzyme arylsulfatase B result in the genetic disorder mucopolysaccharidosis VI. Current treatment for mucopolysaccharidosis VI requires intravenous enzyme replacement therapy which suffers from incomplete biodistribution. Alternative therapeutic approaches based on small molecules acting as enzyme stabilizers or pharmacological chaperones facilitate the transport of mutant enzymes to the lysosome and may offer improved biodistribution. Herein we describe the development of a facile microwave-assisted reductive amination to synthesize

Identifiers

PMID41970838
PMCPMC13063022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.